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The AMD Athlon II X4 645 was a desktop processor with 4 cores. It is part of the Athlon II X4 lineup, using the Propus architecture with Socket AM3. Athlon II X4 645 has 512 KB of L2 cache per core and operates at 3.1 GHz. AMD is making the Athlon II X4 645 on a 45 nm production node using 300 million transistors. The multiplier is locked on Athlon II X4 645, which limits its overclocking potential.

With a TDP of 95 W, the Athlon II X4 645 consumes a good deal of power, so decent cooling is needed. AMD's processor supports DDR3 memory with a dual-channel interface. For communication with other components in the computer, Athlon II X4 645 uses a PCI-Express Gen 2 connection. Although the processor doesn't come with integrated graphics, certain motherboards with compatible chipsets can provide this capability.

Hardware virtualization is available on the Athlon II X4 645, which greatly improves virtual machine performance.

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